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Journal article

Beneficial effect of monoclonal antibody to interleukin 2 receptor on activated T cells in rheumatoid arthritis.

Abstract:

Campath 6, a rat IgG2b monoclonal antibody to the interleukin 2 receptor on activated T cells, was used to treat three patients with active rheumatoid arthritis unresponsive to conventional treatment. Two patients had an excellent response for about three months. There were no significant side effects. The results suggest that activated T cells are of importance in the pathogenesis of rheumatoid arthritis. Although infusions of rat monoclonal antibodies could not be repeated because of the ri...

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Publication status:
Published

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Publisher copy:
10.1136/ard.48.5.428

Authors


Coughlan, RJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Hazleman, BL More by this author
Journal:
Annals of the rheumatic diseases
Volume:
48
Issue:
5
Pages:
428-429
Publication date:
1989-05-05
DOI:
EISSN:
1468-2060
ISSN:
0003-4967
URN:
uuid:b7767582-0cdf-4e4f-b065-5cd8d1854a4e
Source identifiers:
18225
Local pid:
pubs:18225

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