The competitive NMDA antagonist AP5, but not the non-competitive antagonist MK801, induces a delay-related impairment in spatial working memory in rats.

Journal article

Rats were trained to alternate responses on a discrete trial working memory task on a T-maze. In Experiment 1, the rats were then matched for choice accuracy and allocated to three treatment groups. These were: implantation of osmotic minipumps for intraventricular infusion of either (a) 15 mM D-2-amino-5-phosphonopentanoic acid (AP5) or (b) artificial cerebrospinal fluid (VEH); and an unoperated control group (UNOP). In Phase 1 we assessed alternation performance with a minimal delay between...

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Authors: Tonkiss, J; Rawlins, J

• Publication status: Published
• Journal: Experimental brain research
• Volume: 85
• Issue: 2
• Pages: 349-358
• Publication date: 1991-01-01
• DOI: 10.1007/bf00229412
• EISSN: 1432-1106
• ISSN: 0014-4819
• Language: English
• Keywords: Reference Values; Animals; Injections, Intraventricular; Male; Choice Behavior; Rats; Rats, Inbred Strains; 2-Amino-5-phosphonovalerate; Memory; Dizocilpine Maleate; Space Perception; N-Methylaspartate; Cerebral Ventricles