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Safety of Repeated Open-Label Treatment Courses of Intravenous Ofatumumab, a Human Anti-CD20 Monoclonal Antibody, in Rheumatoid Arthritis: Results from Three Clinical Trials.

Abstract:

Objectives
To investigate the safety of ofatumumab retreatment in rheumatoid arthritis.

Methods
Patients with active rheumatoid arthritis participating in two phase III trials (OFA110635 and OFA110634) and a phase II extension trial (OFA111752) received individualised open-label ofatumumab retreatment (700 mg X 2 intravenous infusions two weeks apart) ≥24 weeks following the first course and ≥16 weeks following further courses. Retreatment required evidence of clinical ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0157961

Authors


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Department:
Oxford, MSD, NDORMS, KIR
Role:
Author
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GlaxoSmithKline Pharmaceuticals More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS One Journal website
Volume:
11
Issue:
6
Pages:
320-330
Chapter number:
e0157961
Publication date:
2016-06-23
Acceptance date:
2016-06-05
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uri:b767952c-880b-49f3-8dc3-5c8caea843fa
UUID:
uuid:b767952c-880b-49f3-8dc3-5c8caea843fa
Local pid:
pubs:656055
Paper number:
6

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