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Poor efficacy of antimalarial biguanide-dapsone combinations in the treatment of acute, uncomplicated, falciparum malaria in Thailand.

Abstract:

Combinations of dapsone with proguanil or chlorproguanil have proved effective in the treatment of chloroquine-resistant falciparum malaria in Africa and for prophylaxis in Asia. These combinations have not been used for treatment in areas with multi-drug-resistant parasites such as in Thailand. Combinations of dapsone (approximately 4 mg/kg) plus ether proguanil (approximately 8 mg/kg; DP regimen; N = 10) or chlorproguanil (approximately 1.4 mg/kg; DC regimen; N = 16) were given once a day f...

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Publication status:
Published

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Publisher copy:
10.1080/00034989761454

Authors


Wilairatana, P More by this author
Looareesuwan, S More by this author
Chinwongprom, K More by this author
Amradee, S More by this author
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Journal:
Annals of tropical medicine and parasitology
Volume:
91
Issue:
2
Pages:
125-132
Publication date:
1997-03-05
DOI:
EISSN:
1364-8594
ISSN:
0003-4983
URN:
uuid:b764b2cb-ba16-4ab5-bff1-60a79d38487c
Source identifiers:
45544
Local pid:
pubs:45544

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