Poor efficacy of antimalarial biguanide-dapsone combinations in the treatment of acute, uncomplicated, falciparum malaria in Thailand.

Journal article

Combinations of dapsone with proguanil or chlorproguanil have proved effective in the treatment of chloroquine-resistant falciparum malaria in Africa and for prophylaxis in Asia. These combinations have not been used for treatment in areas with multi-drug-resistant parasites such as in Thailand. Combinations of dapsone (approximately 4 mg/kg) plus ether proguanil (approximately 8 mg/kg; DP regimen; N = 10) or chlorproguanil (approximately 1.4 mg/kg; DC regimen; N = 16) were given once a day f...

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Authors: Wilairatana, P; Kyle, D; Looareesuwan, S; Chinwongprom, K; Amradee, S

• Publication status: Published
• Journal: Annals of tropical medicine and parasitology
• Volume: 91
• Issue: 2
• Pages: 125-132
• Publication date: 1997-03-01
• DOI: 10.1080/00034989761454
• EISSN: 1364-8594
• ISSN: 0003-4983
• Language: English
• Keywords: Animals; Treatment Outcome; Adolescent; Drug Therapy, Combination; Folic Acid Antagonists; Plasmodium falciparum; Follow-Up Studies; Humans; Adult; Female; Dapsone; Parasitemia; Drug Resistance; Proguanil; Malaria, Falciparum; Pilot Projects; Antimalarials; Male; Thailand; Middle Aged