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The GPIHBP1-LPL complex is responsible for the margination of triglyceride-rich lipoproteins in capillaries.

Abstract:

Triglyceride-rich lipoproteins (TRLs) undergo lipolysis by lipoprotein lipase (LPL), an enzyme that is transported to the capillary lumen by an endothelial cell protein, GPIHBP1. For LPL-mediated lipolysis to occur, TRLs must bind to the lumen of capillaries. This process is often assumed to involve heparan sulfate proteoglycans (HSPGs), but we suspected that TRL margination might instead require GPIHBP1. Indeed, TRLs marginate along the heart capillaries of wild-type but not Gpihbp1⁻/⁻ mice,...

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Publication status:
Published

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Publisher copy:
10.1016/j.cmet.2014.01.017

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Journal:
Cell metabolism
Volume:
19
Issue:
5
Pages:
849-860
Publication date:
2014-05-05
DOI:
EISSN:
1932-7420
ISSN:
1550-4131
URN:
uuid:b75b510b-088f-48e6-b1e4-8f2e0c31692a
Source identifiers:
462087
Local pid:
pubs:462087

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