18F-FDG kinetics in locally advanced breast cancer: correlation with tumor blood flow and changes in response to neoadjuvant chemotherapy.

Journal article

UNLABELLED: The aim of this study was to characterize the biologic response of locally advanced breast cancer (LABC) to chemotherapy using (15)O-water-derived blood flow measurements and (18)F-FDG-derived glucose metabolism rate parameters. METHODS: Thirty-five LABC patients underwent PET with (15)O-water and (18)F-FDG before neoadjuvant chemotherapy and 2 mo after the initiation of treatment. Kinetic analysis for (15)O-water was performed using a single tissue compartment model to calculate ...

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Authors: Tseng, J; Dunnwald, L; Schubert, E; Link, J; Minoshima, S

• Publication status: Published
• Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
• Volume: 45
• Issue: 11
• Pages: 1829-1837
• Publication date: 2004-11-01
• EISSN: 1535-5667
• ISSN: 0161-5505
• Language: English
• Keywords: Humans; Antineoplastic Agents; Glucose; Fluorodeoxyglucose F18; Chemotherapy, Adjuvant; Treatment Outcome; Breast; Breast Neoplasms; Kinetics; Radiopharmaceuticals; Image Interpretation, Computer-Assisted; Statistics as Topic; Blood Flow Velocity