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Helicobacter pylori genome evolution during human infection.

Abstract:

High genetic diversity is a hallmark of the gastric pathogen Helicobacter pylori. We used 454 sequencing technology to perform whole-genome comparisons for five sets of H. pylori strains that had been sequentially cultured from four chronically infected Colombians (isolation intervals=3-16 y) and one human volunteer experimentally infected with H. pylori as part of a vaccine trial. The four sets of genomes from Colombian H. pylori differed by 27-232 isolated SNPs and 16-441 imported clusters ...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.1018444108

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Institution:
University of Oxford
Department:
Oxford, MPLS, Statistics
Role:
Author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
108
Issue:
12
Pages:
5033-5038
Publication date:
2011-03-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:b745258c-7846-4022-8b40-d9b643912a9c
Source identifiers:
124334
Local pid:
pubs:124334

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