Exosome mimetics: a novel class of drug delivery systems.

Journal article

The identification of extracellular phospholipid vesicles as conveyors of cellular information has created excitement in the field of drug delivery. Biological therapeutics, including short interfering RNA and recombinant proteins, are prone to degradation, have limited ability to cross biological membranes, and may elicit immune responses. Therefore, delivery systems for such drugs are under intensive investigation. Exploiting extracellular vesicles as carriers for biological therapeutics is...

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Authors: Kooijmans, SA; Vader, P; van Dommelen, S; van Solinge, W; Schiffelers, R

• Journal: International journal of nanomedicine
• Volume: 7
• Pages: 1525-1541
• Publication date: 2012-01-01
• DOI: 10.2147/ijn.s29661
• EISSN: 1178-2013
• ISSN: 1176-9114
• Language: English
• Keywords: Drug Carriers; Cell Adhesion Molecules; Nanomedicine; Biomimetic Materials; Humans; Exosomes; Liposomes; Nanotechnology; Animals; RNA, Small Interfering; Tetraspanins; Biotechnology; Membrane Lipids; Drug Delivery Systems; Membrane Proteins