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The levosimendan metabolite OR-1896 elicits vasodilation by activating the K(ATP) and BK(Ca) channels in rat isolated arterioles.

Abstract:

1. We characterized the vasoactive effects of OR-1896, the long-lived metabolite of the inodilator levosimendan, in coronary and skeletal muscle microvessels. 2. The effect of OR-1896 on isolated, pressurized (80 mmHg) rat coronary and gracilis muscle arteriole (approximately 150 microm) diameters was investigated by videomicroscopy. 3. OR-1896 elicited concentration-dependent (1 nM-10 microM) dilations in coronary (maximal dilation: 66+/-6%, relative to that in Ca2+-free solutions; pD2: 7.16...

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Publication status:
Published

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Publisher copy:
10.1038/sj.bjp.0706781

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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
Journal:
British journal of pharmacology
Volume:
148
Issue:
5
Pages:
696-702
Publication date:
2006-07-05
DOI:
EISSN:
1476-5381
ISSN:
0007-1188
URN:
uuid:b7355164-ea2f-4627-adba-61a17b8f8110
Source identifiers:
164664
Local pid:
pubs:164664

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