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FtsK Is a DNA motor protein that activates chromosome dimer resolution by switching the catalytic state of the XerC and XerD recombinases.

Abstract:

FtsK acts at the bacterial division septum to couple chromosome segregation with cell division. We demonstrate that a truncated FtsK derivative, FtsK(50C), uses ATP hydrolysis to translocate along duplex DNA as a multimer in vitro, consistent with FtsK having an in vivo role in pumping DNA through the closing division septum. FtsK(50C) also promotes a complete Xer recombination reaction between dif sites by switching the state of activity of the XerCD recombinases so that XerD makes the first...

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Publication status:
Published

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Journal:
Cell
Volume:
108
Issue:
2
Pages:
195-205
Publication date:
2002-01-05
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
URN:
uuid:b72661e7-1d27-43cd-adf7-e1d6b01b6340
Source identifiers:
199791
Local pid:
pubs:199791

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