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Early changes in emotional processing as a marker of clinical response to SSRI treatment in depression

Abstract:

Antidepressant treatment reduces behavioural and neural markers of negative emotional bias early in treatment and has been proposed as a mechanism of antidepressant drug action. Here, we provide a critical test of this hypothesis by assessing whether neural markers of early emotional processing changes predict later clinical response in depression. Thirty-five unmedicated patients with major depression took the serotonin re-uptake inhibitor (SSRI), escitalopram (10 mg), over 6 weeks, and were...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/tp.2016.130

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Department:
Oxford, MSD, Psychiatry
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Department:
Oxford, MSD, Psychiatry
Norbury, Ray More by this author
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Department:
Oxford, MSD, Psychiatry
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Department:
Oxford, MSD, Psychiatry
Publisher:
Nature Publishing Group Publisher's website
Journal:
Translational Psychiatry Journal website
Volume:
6
Pages:
Article number: e957
Publication date:
2016-11-22
Acceptance date:
2016-06-01
DOI:
EISSN:
2158-3188
Pubs id:
pubs:639055
URN:
uri:b7203837-593a-4fa4-a898-637b8bd1941b
UUID:
b7203837-593a-4fa4-a898-637b8bd1941b
Local pid:
pubs:639055

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