Journal article icon

Journal article

Refocusing of B-cell responses following a single amino acid substitution in an antigen.

Abstract:

Intranasal immunization of BALB/c strain mice was carried out using baculovirus-derived human chorionic gonadotrophin (hCG) beta-chain, together with Escherichia coli heat-labile enterotoxin. Gonadotrophin-reactive immunoglobulin A (IgA) was induced in a remote mucosal site, the lung, in addition to a systemic IgG response. The extensive sequence homology with luteinizing hormone (LH) results in the production of LH cross-reactive antibodies when holo-hCG is used as an immunogen. In contrast ...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Chiesa, MD More by this author
Martensen, PM More by this author
Simmons, C More by this author
Porakishvili, N More by this author
Justesen, J More by this author
Expand authors...
Journal:
Immunology
Volume:
103
Issue:
2
Pages:
172-178
Publication date:
2001-06-05
DOI:
EISSN:
1365-2567
ISSN:
0019-2805
URN:
uuid:b71aacd7-3061-43de-9cda-762b87e7efaf
Source identifiers:
98268
Local pid:
pubs:98268

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP