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Journal article

Refocusing of B-cell responses following a single amino acid substitution in an antigen.

Abstract:

Intranasal immunization of BALB/c strain mice was carried out using baculovirus-derived human chorionic gonadotrophin (hCG) beta-chain, together with Escherichia coli heat-labile enterotoxin. Gonadotrophin-reactive immunoglobulin A (IgA) was induced in a remote mucosal site, the lung, in addition to a systemic IgG response. The extensive sequence homology with luteinizing hormone (LH) results in the production of LH cross-reactive antibodies when holo-hCG is used as an immunogen. In contrast ...

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Publication status:
Published

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Journal:
Immunology
Volume:
103
Issue:
2
Pages:
172-178
Publication date:
2001-06-05
DOI:
EISSN:
1365-2567
ISSN:
0019-2805
URN:
uuid:b71aacd7-3061-43de-9cda-762b87e7efaf
Source identifiers:
98268
Local pid:
pubs:98268

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