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Genome-wide comparison of African-ancestry populations from CARe and other cohorts reveals signals of natural selection.

Abstract:

The study of recent natural selection in human populations has important applications to human history and medicine. Positive natural selection drives the increase in beneficial alleles and plays a role in explaining diversity across human populations. By discovering traits subject to positive selection, we can better understand the population level response to environmental pressures including infectious disease. Our study examines unusual population differentiation between three large data ...

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Publisher copy:
10.1016/j.ajhg.2011.07.025

Authors


Patterson, N More by this author
Pasaniuc, B More by this author
Zaitlen, N More by this author
Genovese, G More by this author
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Journal:
American journal of human genetics
Volume:
89
Issue:
3
Pages:
368-381
Publication date:
2011-09-05
DOI:
EISSN:
1537-6605
ISSN:
0002-9297
URN:
uuid:b70ae846-8e22-42f4-8dd3-ffa07b40fbe5
Source identifiers:
175203
Local pid:
pubs:175203

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