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Clonal selection, clonal senescence, and clonal succession: the evolution of the T cell response to infection with a persistent virus.

Abstract:

We have analyzed the CD8(+) T cell response to EBV and find that a larger primary burst size is associated with proportionally greater decay during the development of memory. Consequently, immunodominance and clonal dominance are less marked in memory than primary responses. An intuitive interpretation of this finding is that there is a limit to the number of cell divisions a T cell clone can undergo, and that the progeny of clones that have expanded massively during a primary immune response...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.168.7.3309

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
Journal:
Journal of Immunology
Volume:
168
Issue:
7
Pages:
3309-3317
Publication date:
2002-04-01
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Source identifiers:
38160

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