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Clonal selection, clonal senescence, and clonal succession: the evolution of the T cell response to infection with a persistent virus.

Abstract:

We have analyzed the CD8(+) T cell response to EBV and find that a larger primary burst size is associated with proportionally greater decay during the development of memory. Consequently, immunodominance and clonal dominance are less marked in memory than primary responses. An intuitive interpretation of this finding is that there is a limit to the number of cell divisions a T cell clone can undergo, and that the progeny of clones that have expanded massively during a primary immune response...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.168.7.3309

Authors


Davenport, MP More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Callan, MF More by this author
Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
168
Issue:
7
Pages:
3309-3317
Publication date:
2002-04-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:b70389c4-f467-434a-838b-07a63dd7b60c
Source identifiers:
38160
Local pid:
pubs:38160

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