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Journal article

Modified vaccinia virus Ankara-based vaccine vectors induce apoptosis in dendritic cells draining from the skin via both the extrinsic and intrinsic caspase pathways, preventing efficient antigen presentation.

Abstract:

Dendritic cells (DC) are potent antigen-presenting cells and central to the induction of immune responses following infection or vaccination. The collection of DC migrating from peripheral tissues by cannulation of the afferent lymphatic vessels provides DC which can be used directly ex vivo without extensive in vitro manipulations. We have previously used bovine migrating DC to show that recombinant human adenovirus 5 vectors efficiently transduce afferent lymph migrating DEC-205(+) CD11c(+)...

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Publication status:
Published

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Publisher copy:
10.1128/jvi.00264-12

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Role:
Author
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Journal:
Journal of virology
Volume:
86
Issue:
10
Pages:
5452-5466
Publication date:
2012-05-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:b700d703-a4cd-428b-9277-b9c4a765bbbe
Source identifiers:
316315
Local pid:
pubs:316315

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