- Abstract:
-
Tumour cells exploit both genetic and adaptive means to survive and proliferate in hypoxic microenvironments, resulting in the outgrowth of more aggressive tumour cell clones. Direct measurements of tumour oxygenation, and surrogate markers of the hypoxic response in tumours (for instance, hypoxia inducible factor-1alpha, carbonic anhydrase 9 and glucose transporter-1) are well-established prognostic markers in solid cancers. However, individual markers do not fully capture the complex, dynam...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1111/j.1582-4934.2009.00944.x
-
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- Journal:
- Journal of cellular and molecular medicine
- Volume:
- 14
- Issue:
- 1-2
- Pages:
- 18-29
- Publication date:
- 2010-01-05
- DOI:
- EISSN:
-
1582-4934
- ISSN:
-
1582-1838
- URN:
-
uuid:b6feaeaf-3153-46b8-bfd2-b2abf8df944b
- Source identifiers:
-
125312
- Local pid:
- pubs:125312
- Copyright date:
- 2010
Journal article
Assessment of tumour hypoxia for prediction of response to therapy and cancer prognosis.
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