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Journal article

Assessment of tumour hypoxia for prediction of response to therapy and cancer prognosis.

Abstract:

Tumour cells exploit both genetic and adaptive means to survive and proliferate in hypoxic microenvironments, resulting in the outgrowth of more aggressive tumour cell clones. Direct measurements of tumour oxygenation, and surrogate markers of the hypoxic response in tumours (for instance, hypoxia inducible factor-1alpha, carbonic anhydrase 9 and glucose transporter-1) are well-established prognostic markers in solid cancers. However, individual markers do not fully capture the complex, dynam...

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Publication status:
Published

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Journal:
Journal of cellular and molecular medicine
Volume:
14
Issue:
1-2
Pages:
18-29
Publication date:
2010-01-05
DOI:
EISSN:
1582-4934
ISSN:
1582-1838
URN:
uuid:b6feaeaf-3153-46b8-bfd2-b2abf8df944b
Source identifiers:
125312
Local pid:
pubs:125312

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