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Double dissociation of spike timing–dependent potentiation and depression by subunit-preferring NMDA receptor antagonists in mouse barrel cortex

Abstract:

Spike timing–dependent plasticity (STDP) is a strong candidate for an N-methyl-D-aspartate (NMDA) receptor-dependent form of synaptic plasticity that could underlie the development of receptive field properties in sensory neocortices. Whilst induction of timing-dependent long-term potentiation (t-LTP) requires postsynaptic NMDA receptors, timing-dependent long-term depression (t-LTD) requires the activation of presynaptic NMDA receptors at layer 4-to-layer 2/3 synapses in barrel cortex. He...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/cercor/bhp067

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Institution:
University of Oxford
Research group:
Neuronal Oscillations Group
Department:
Medical Sciences Division - Physiology,Anatomy and Genetics,Department of
More by this author
Institution:
University of Oxford
Research group:
Neuronal Oscillations Group
Department:
Medical Sciences Division - Physiology,Anatomy and Genetics,Department of
More by this author
Institution:
University of Oxford
Research group:
Neuronal Oscillations Group
Department:
Medical Sciences Division - Physiology,Anatomy and Genetics,Department of
More by this author
Institution:
University of Oxford
Research group:
Neuronal Oscillations Group
Department:
Medical Sciences Division - Physiology,Anatomy and Genetics,Department of
More by this author
Institution:
Novartis Institutes for BioMedical Research
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Funding agency for:
Abhishek Banerjee
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Funding agency for:
Antonio Rodríguez-Moreno
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Funding agency for:
Susanna B. Mierau
Doris Field CT More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
Cerebral Cortex Journal website
Volume:
19
Issue:
12
Pages:
2959-2969
Publication date:
2009-12-05
DOI:
EISSN:
1460-2199
ISSN:
1047-3211
URN:
uuid:b6fa91d0-8754-49e0-9914-fbfde896b09a
Local pid:
ora:7793

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