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Thesis

Identification and characterisation of epigenetic mechanisms in osteoblast differentiation of human mesenchymal stem cells

Abstract:

A major therapeutic challenge in musculoskeletal regenerative medicine is how to effectively replenish bone tissue lost due to pathological conditions such as fracture, osteoporosis, or rheumatoid arthritis. Mesenchymal stem cells are currently investigated for applications in bone-tissue engineering and human bone marrow-derived mesenchymal stem cells (hMSCs) could be a promising source for generation of tissue-engineered bone. However, the therapeutic potential of MSCs has not been fully...

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Institution:
University of Oxford
Oxford college:
St Catherine's College
Department:
Medical Sciences Division - NDORMS (Nuffield Department of Orthopaedics,Rheumatology and Musculoskeletal Sciences)

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Role:
Supervisor
Role:
Supervisor
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:b6f7a356-b20f-4988-8770-8bebc233bf4b
Local pid:
ora:11435

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