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Genetics of fetal hemoglobin in Tanzanian and British patients with sickle cell anemia.

Abstract:

Fetal hemoglobin (HbF, α(2)γ(2)) is a major contributor to the remarkable phenotypic heterogeneity of sickle cell anemia (SCA). Genetic variation at 3 principal loci (HBB cluster on chromosome 11p, HBS1L-MYB region on chromosome 6q, and BCL11A on chromosome 2p) have been shown to influence HbF levels and disease severity in β-thalassemia and SCA. Previous studies in SCA, however, have been restricted to populations from the African diaspora, which include multiple genealogies. We have investi...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
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Journal:
Blood
Volume:
117
Issue:
4
Pages:
1390-1392
Publication date:
2011-01-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:b6f43923-7cc1-4390-8285-738cbba74493
Source identifiers:
104855
Local pid:
pubs:104855

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