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Differential Plasmodium falciparum surface antigen expression among children with Malarial Retinopathy

Abstract:

Retinopathy provides a window into the underlying pathology of life-threatening malarial coma (“cerebral malaria”), allowing differentiation between 1) coma caused by sequestration of Plasmodium falciparum-infected erythrocytes in the brain and 2) coma with other underlying causes. Parasite sequestration in the brain is mediated by PfEMP1; a diverse parasite antigen that is inserted into the surface of infected erythrocytes and adheres to various host receptors. PfEMP1 sub-groups called “DC8”...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/srep18034

Authors


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Role:
Author
ORCID:
0000-0001-7989-2125
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Psychiatry
Role:
Author
ORCID:
0000-0002-3934-5132
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Role:
Author
ORCID:
0000-0002-2663-2765
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Grant:
083744
084535
103956
092654
084538
092741
099782
Publisher:
Springer Nature Publisher's website
Journal:
Scientific reports Journal website
Issue:
1
Publication date:
2015-12-14
Acceptance date:
2015-11-10
DOI:
ISSN:
2045-2322
Pmid:
26657042
Source identifiers:
581304
Language:
English
Keywords:
Pubs id:
pubs:581304
UUID:
uuid:b6ef3aa5-3825-4cd8-bd15-1af1349f2198
Local pid:
pubs:581304
Deposit date:
2018-10-02

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