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Chemoselective formation and reaction of densely functionalised bicyclic tetramic acids and their biological activity

Abstract:
Weinreb amide derivatives of tetramates may be effectively accessed by chemoselective Dieckmann reaction, and further react with Grignards in a fully chemoselective reaction, giving rise to unsaturated acyl derivatives not easily available by other routes. These systems are strong chelators of calcium, and some show potent activity against Gram positive bacteria, and one is a first-in-class proteasome inhibitor.
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1002/ejoc.201701393

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More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry; Organic Chemistry
Oxford college:
St Peters College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry; Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry; Organic Chemistry
Role:
Author
More from this funder
Funding agency for:
Josa-Culleré, L
More from this funder
Funding agency for:
Towers, C
Publisher:
Wiley Publisher's website
Journal:
European Journal of Organic Chemistry Journal website
Volume:
2017
Issue:
47
Pages:
7055-7059
Publication date:
2017-12-18
Acceptance date:
2017-10-09
DOI:
EISSN:
1099-0690
ISSN:
1434-193X
Pubs id:
pubs:745892
URN:
uri:b6ee0e01-2655-48c6-87e3-decd0524baa1
UUID:
uuid:b6ee0e01-2655-48c6-87e3-decd0524baa1
Local pid:
pubs:745892

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