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Crystal structure of the N-terminal domain of sialoadhesin in complex with 3' sialyllactose at 1.85 A resolution.

Abstract:

The structure of the functional N-terminal domain from the extracellular region of the cell surface receptor sialoadhesin has been determined in complex with the oligosaccharide 3' sialyllactose. This provides structural information for the siglec family of proteins. The structure conforms to the V-set immunoglobulin-like fold but contains several distinctive features, including an intra-beta sheet disulphide and a splitting of the standard beta strand G into two shorter strands. These novel ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
Role:
Author
Journal:
Molecular cell
Volume:
1
Issue:
5
Pages:
719-728
Publication date:
1998-04-05
DOI:
EISSN:
1097-4164
ISSN:
1097-2765
URN:
uuid:b6e16318-85f7-4569-8738-516d4796aa67
Source identifiers:
30213
Local pid:
pubs:30213

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