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Journal article

Therapeutic efficacy of multiple intravenous infusions of anti-tumor necrosis factor alpha monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis.

Abstract:

OBJECTIVE: To evaluate the efficacy, pharmacokinetics, immunogenicity, and safety of multiple infusions of a chimeric monoclonal anti-tumor necrosis factor alpha antibody (cA2) (infliximab; Remicade, Centocor, Malvern, PA) given alone or in combination with low-dose methotrexate (MTX) in rheumatoid arthritis (RA) patients. METHODS: In a 26-week, double-blind, placebo-controlled, multicenter trial, 101 patients with active RA exhibiting an incomplete response or flare of disease activity while...

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Publication status:
Published

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Authors


Breedveld, FC More by this author
Kalden, JR More by this author
Smolen, JS More by this author
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Journal:
Arthritis and rheumatism
Volume:
41
Issue:
9
Pages:
1552-1563
Publication date:
1998-09-05
DOI:
EISSN:
1529-0131
ISSN:
0004-3591
URN:
uuid:b6cd2920-1f1e-459a-a290-55e23d9d26e6
Source identifiers:
481592
Local pid:
pubs:481592

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