Journal article
Looking glass inhibitors: synthesis of a potent naringinase inhibitor L-DIM [1,4-dideoxy-1,4-imino-L-mannitol], the enantiomer of DIM [1,4-dideoxy-1,4-imino-D-mannitol] a potent alpha-D-mannosidase inhibitor
- Abstract:
-
The synthesis of l-DIM [1,4-dideoxy-1,4-imino-l-mannitol] and of 1,4-imino-d-glycero-l-talo-heptitol from d-glycero-d-gulo-heptono-1,4-lactone depends on the use of pentan-3-one to form two five ring ketals as described by Burke, rather than the formation of one five ring and one six ring ketal formed with acetone. l-DIM, the enantiomer of the potent α-d-mannosidase inhibitor DIM [1,4-dideoxy-1,4-imino-d-mannitol] is a good inhibitor of naringinase (an α-l-rhamnosidase) with a K of 3.63 μM. 1...
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- Publication status:
- Published
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- Publisher copy:
- 10.1016/j.tetasy.2007.01.010
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Bibliographic Details
- Journal:
- TETRAHEDRON-ASYMMETRY
- Volume:
- 18
- Issue:
- 2
- Pages:
- 282-289
- Publication date:
- 2007-02-14
- DOI:
- EISSN:
-
1362-511X
- ISSN:
-
0957-4166
- Source identifiers:
-
40274
Item Description
- Pubs id:
-
pubs:40274
- UUID:
-
uuid:b6cd25c8-cce6-4bf4-a7c1-936dbbb8dbaa
- Local pid:
- pubs:40274
- Deposit date:
- 2012-12-19
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- Copyright date:
- 2007
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