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Direct comparison of cognitive facilitation by physostigmine and tetrahydroaminoacridine in two primate models.

Abstract:

Cognitive facilitation by physostigmine and tetrahydroaminoacridine (THA) was compared in two primate models. Disruption of spatial delayed response performance by scopolamine (0.03 mg/kg) was fully reversed by coadministration of 5 doses of physostigmine in the range 0.03-0.08 mg/kg, but by only one dose (4.0 mg/kg) of THA; partial reversal of some effects of scopolamine was observed at 1 and 3 mg/kg of THA. Visual recognition memory was enhanced following treatment with 4 doses of physostig...

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Publication status:
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Authors


Rupniak, NM More by this author
Samson, NA More by this author
Steventon, MJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Journal:
Neurobiology of aging
Volume:
11
Issue:
6
Pages:
609-613
Publication date:
1990
DOI:
EISSN:
1558-1497
ISSN:
0197-4580
URN:
uuid:b6ccef73-2baf-4628-a459-cc421475c7bf
Source identifiers:
12910
Local pid:
pubs:12910

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