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Response heterogeneity of human macrophages to ATP is associated with P2X7 receptor expression but not to polymorphisms in the P2RX7 promoter.

Abstract:

A region 2 kb upstream of exon 1 of the P2X7 gene was sequenced using DNA from nine healthy individuals who exhibited three different ATP response phenotypes (i.e. high, low and interferon gamma-inducible). Five single nucleotide polymorphisms were identified within the nine donor promoter sequences but none were associated with a specific ATP response phenotype. A P2X7 loss of function polymorphism (1513 in exon 13) was also screened for within donor DNA but no response associations were ide...

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Publication status:
Published

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Authors


Campbell, SJ More by this author
Kumararatne, DS More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute, Biomedical Research Centre
Lammas, DA More by this author
Journal:
FEBS letters
Volume:
531
Issue:
2
Pages:
127-131
Publication date:
2002-11-05
DOI:
EISSN:
1873-3468
ISSN:
0014-5793
URN:
uuid:b6cbfe1c-ca3c-452a-adc8-44483aaf421e
Source identifiers:
53867
Local pid:
pubs:53867

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