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Cutting edge: anti-CD154 therapeutic antibodies induce infectious transplantation tolerance.

Abstract:

Nondepleting anti-CD154 (CD40 ligand) mAbs have proven effective in inducing transplantation tolerance in rodents and primates. In the induction phase, anti-CD154 Ab therapy is known to enhance apoptosis of Ag reactive T cells. However, this may not be the sole explanation for tolerance, as we show in this study that tolerance is maintained through a dominant regulatory mechanism which, like tolerance induced with CD4 Abs, manifests as infectious tolerance. Therefore, tolerance induced with a...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.165.9.4783

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Journal of Immunology
Volume:
165
Issue:
9
Pages:
4783-4786
Publication date:
2000-11-01
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Source identifiers:
20099

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