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Farnesyltransferase inhibitors as radiation sensitizers.

Abstract:

PURPOSE: The inhibition of activated Ras combined with radiotherapy was identified as a potential method for radiosensitization. MATERIALS AND METHODS: Immunoblotting was used to control for prenylation inhibition of the respective Ras isoforms and for changes in activity of downstream proteins. Clonogenic assays with human and rodent tumour cell lines and transfected cell lines served for the testing of radiosensitivity. Xenograft tumours were treated with farnesyl transferase inhibitors and...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
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Journal:
International journal of radiation biology
Volume:
79
Issue:
7
Pages:
569-576
Publication date:
2003-07-01
DOI:
EISSN:
1362-3095
ISSN:
0955-3002
Source identifiers:
118197
Language:
English
Keywords:
Pubs id:
pubs:118197
UUID:
uuid:b6c50369-9f0c-45df-8ea4-9c5ab2aa6367
Local pid:
pubs:118197
Deposit date:
2012-12-19

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