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Journal article

Unexpected protective role for Toll-like receptor 3 in the arterial wall.

Abstract:

The critical role of Toll-like receptors (TLRs) in mammalian host defense has been extensively explored in recent years. The capacity of about 10 TLRs to recognize conserved patterns on many bacterial and viral pathogens is remarkable. With so few receptors, cross-reactivity with self-tissue components often occurs. Previous studies have frequently assigned detrimental roles to TLRs, in particular to TLR2 and TLR4, in immune and cardiovascular disease. Using human and murine systems, we have ...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.1018515108

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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
108
Issue:
6
Pages:
2372-2377
Publication date:
2011-02-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:b6bd2d45-85ec-440b-a121-e60412ede107
Source identifiers:
224578
Local pid:
pubs:224578

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