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RNA polymerase mutations cause cephalosporin resistance in clinical Neisseria gonorrhoeae isolates

Abstract:

Increasing Neisseria gonorrhoeae resistance to ceftriaxone, the last antibiotic recommended for empiric gonorrhea treatment, poses an urgent public health threat. However, the genetic basis of reduced susceptibility to ceftriaxone is not completely understood: while most ceftriaxone resistance in clinical isolates is caused by target site mutations in penA, some isolates lack these mutations. We show that penA-independent ceftriaxone resistance has evolved multiple times through distinct muta...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.7554/elife.51407

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Role:
Author
ORCID:
0000-0002-7849-8078
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Role:
Author
ORCID:
0000-0001-8268-6285
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Publisher:
eLife Sciences Publications Publisher's website
Journal:
eLife Journal website
Volume:
9
Article number:
e51407
Publication date:
2020-02-03
Acceptance date:
2020-02-01
DOI:
EISSN:
2050-084X
ISSN:
2050-084X
Pmid:
32011233
Language:
English
Keywords:
Pubs id:
1085370
Local pid:
pubs:1085370
Deposit date:
2020-10-20

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