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Staging/typing of Lewy body related α-synuclein pathology: a study of the BrainNet Europe Consortium

Abstract:

When 22 members of the BrainNet Europe (BNE) consortium assessed 31 cases with α-synuclein (αS) immunoreactive (IR) pathology applying the consensus protocol described by McKeith and colleagues in 2005, the inter-observer agreement was 80%, being lowest in the limbic category (73%). When applying the staging protocol described by Braak and colleagues in 2003, agreement was only 65%, and in some cases as low as 36%. When modifications of these strategies, i.e., McKeith’s protocol by Leverenz a...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1007/s00401-009-0523-2

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Publisher:
Springer-Verlag Publisher's website
Journal:
Acta Neuropathologica Journal website
Volume:
117
Issue:
6
Pages:
635-652
Publication date:
2009-06-05
DOI:
EISSN:
1432-0533
ISSN:
0001-6322
URN:
uuid:b6b6f5e0-ab57-4592-a341-aee72db0ec6a
Source identifiers:
579207
Local pid:
pubs:579207

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