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Association of gout with brain reserve and vulnerability to neurodegenerative disease

Abstract:

Objective To assess the associations between gout, brain structure, and neurodegenerative disease incidence.

Methods Using observational and Mendelian randomization analyses we investigated causal relationships between gout and brain health. Exposures included gout diagnosis (from self-report, linked health records and death records) and genetically proxied gout and serum urate. Outcomes were neuroimaging markers of brain structure and neurodegener...

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Publication status:
Published
Peer review status:
Not peer reviewed

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Publisher copy:
10.1101/2022.11.09.22282119

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Role:
Author
ORCID:
0000-0002-8408-0372
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
ORCID:
0000-0002-0630-8204
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Oxford college:
Linacre College
Role:
Author
ORCID:
0000-0002-5190-7038
Host title:
Cold Spring Harbor Laboratory
Publication date:
2022-11-13
DOI:
Language:
English
Pubs id:
1304053
Local pid:
pubs:1304053
Deposit date:
2022-11-14

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