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Journal article

Micro-SPECT/CT with 111In-DTPA-pertuzumab sensitively detects trastuzumab-mediated HER2 downregulation and tumor response in athymic mice bearing MDA-MB-361 human breast cancer xenografts.

Abstract:

UNLABELLED: Pertuzumab is a HER2 dimerization inhibitor that binds to an epitope unique from that of trastuzumab. Our objective was to determine whether SPECT with (111)In-diethylenetriaminepentaacetic acid-pertuzumab ((111)In-DTPA-pertuzumab) could sensitively detect an early molecular response to trastuzumab manifested by HER2 downregulation and a later tumor response revealed by a decreased number of HER2-positive viable tumor cells. METHODS: Changes in HER2 density in SKBr-3 and MDA-MB-3...

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Publication status:
Published

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Publisher copy:
10.2967/jnumed.109.062224

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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
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Journal:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Volume:
50
Issue:
8
Pages:
1340-1348
Publication date:
2009-08-01
DOI:
EISSN:
1535-5667
ISSN:
0161-5505
Source identifiers:
271308

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