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Journal article

Assessment of T-dependent and T-independent immune responses in cattle using a B cell ELISPOT assay.

Abstract:

Understanding the mechanisms that maintain protective antibody levels after immunisation is important for vaccine design. In this study, we have determined the kinetics of plasma and memory B cells detectable in the blood of cattle immunised with model T-dependent or T-independent antigens. Immunisation with the T-D antigen resulted in an expansion of TNP-specific plasma cells post-TNP primary and booster immunisations, which was associated with increased titres of TNP-specific IgG antibodies...

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Publication status:
Published

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Publisher copy:
10.1186/1297-9716-43-68

Authors


Lefevre, EA More by this author
Prentice, H More by this author
Gubbins, S More by this author
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Journal:
Veterinary research
Volume:
43
Issue:
1
Pages:
68
Publication date:
2012
DOI:
EISSN:
1297-9716
ISSN:
0928-4249
URN:
uuid:b6adc3f2-8ea1-48f9-af24-1a8dc274009f
Source identifiers:
354026
Local pid:
pubs:354026

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