- Abstract:
-
Understanding the mechanisms that maintain protective antibody levels after immunisation is important for vaccine design. In this study, we have determined the kinetics of plasma and memory B cells detectable in the blood of cattle immunised with model T-dependent or T-independent antigens. Immunisation with the T-D antigen resulted in an expansion of TNP-specific plasma cells post-TNP primary and booster immunisations, which was associated with increased titres of TNP-specific IgG antibodies...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1186/1297-9716-43-68
-
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- Journal:
- Veterinary research
- Volume:
- 43
- Issue:
- 1
- Pages:
- 68
- Publication date:
- 2012
- DOI:
- EISSN:
-
1297-9716
- ISSN:
-
0928-4249
- URN:
-
uuid:b6adc3f2-8ea1-48f9-af24-1a8dc274009f
- Source identifiers:
-
354026
- Local pid:
- pubs:354026
- Copyright date:
- 2012
Journal article
Assessment of T-dependent and T-independent immune responses in cattle using a B cell ELISPOT assay.
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