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Journal article

The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance.

Abstract:

The role of autophagy, a lysosomal degradation pathway which prevents cellular damage, in the maintenance of adult mouse hematopoietic stem cells (HSCs) remains unknown. Although normal HSCs sustain life-long hematopoiesis, malignant transformation of HSCs leads to leukemia. Therefore, mechanisms protecting HSCs from cellular damage are essential to prevent hematopoietic malignancies. In this study, we crippled autophagy in HSCs by conditionally deleting the essential autophagy gene Atg7 in t...

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Publication status:
Published

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Publisher copy:
10.1084/jem.20101145

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Journal:
Journal of experimental medicine
Volume:
208
Issue:
3
Pages:
455-467
Publication date:
2011-03-01
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
Source identifiers:
120142
Language:
English
Keywords:
Pubs id:
pubs:120142
UUID:
uuid:b6a209cb-6b73-40d2-9334-156f96ed33d5
Local pid:
pubs:120142
Deposit date:
2012-12-19

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