Journal article icon

Journal article

Formalin inactivation of vesicular stomatitis virus impairs T-cell- but not T-help-independent B-cell responses.

Abstract:

The effects of formalin on the infectivity and immunogenicity of vesicular stomatitis virus (VSV) serotype Indiana were investigated. We found that formalin inactivation of VSV prevents infection of Vero cells in a concentration- and time-dependent manner, as shown by fluorometric cell analysis and inhibition of plaque formation. Inactivated VSV failed to induce significant cytotoxic T-lymphocyte responses in vivo or after restimulation in vitro. In contrast, the early immunoglobulin M (IgM) ...

Expand abstract
Publication status:
Published

Actions


Authors


Journal:
Journal of virology
Volume:
67
Issue:
7
Pages:
3917-3922
Publication date:
1993-07-05
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:b6a0cf92-5811-46d8-a9fa-1a4861169cfa
Source identifiers:
469197
Local pid:
pubs:469197

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP