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Journal article

Base excision repair targets for cancer therapy.

Abstract:

Cellular DNA repair is a frontline system that is responsible for maintaining genome integrity and thus preventing premature aging and cancer by repairing DNA lesions and strand breaks caused by endogenous and exogenous mutagens. However, it is also the principal cellular system in cancer cells that counteracts the killing effect of the major cancer treatments e.g. chemotherapy and ionizing radiation. The major goal of this review is to critically exam the base excision repair pathway and mec...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
Journal:
American journal of cancer research
Volume:
1
Issue:
7
Pages:
845-851
Publication date:
2011-01-01
EISSN:
2156-6976
ISSN:
2156-6976
Source identifiers:
193323
Language:
English
Keywords:
Pubs id:
pubs:193323
UUID:
uuid:b69c4d9f-202e-4f65-bc41-c08832b13a44
Local pid:
pubs:193323
Deposit date:
2012-12-19

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