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The crystal structure of the RhoA-AKAP-Lbc DH-PH domain complex.

Abstract:

The RhoGEF (Rho GTPase guanine-nucleotide-exchange factor) domain of AKAP-Lbc (A-kinase-anchoring protein-Lbc, also known as AKAP13) catalyses nucleotide exchange on RhoA and is involved in the development of cardiac hypertrophy. The RhoGEF activity of AKAP-Lbc has also been implicated in cancer. We have determined the X-ray crystal structure of the complex between RhoA-GDP and the AKAP-Lbc RhoGEF [DH (Dbl-homologous)-PH (pleckstrin homology)] domain to 2.1 Å (1 Å = 0.1 nm) resolution. The st...

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Publication status:
Published

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Publisher copy:
10.1042/bj20140606

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Author
Publisher:
Portland Press Ltd
Journal:
Biochemical journal More from this journal
Volume:
464
Issue:
2
Pages:
231-239
Publication date:
2014-12-01
DOI:
EISSN:
1470-8728
ISSN:
0264-6021
Language:
English
Keywords:
Pubs id:
pubs:492821
UUID:
uuid:b69ac5ee-6e58-4990-93e4-4ebc2d069808
Local pid:
pubs:492821
Source identifiers:
492821
Deposit date:
2014-12-28

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