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MCM2-7 proteins are essential components of prereplicative complexes that accumulate cooperatively in the nucleus during G1-phase and are required to establish, but not maintain, the S-phase checkpoint.

Abstract:

A prereplicative complex (pre-RC) of proteins is assembled at budding yeast origins of DNA replication during the G1-phase of the cell cycle, as shown by genomic footprinting. The proteins responsible for this prereplicative footprint have yet to be identified but are likely to be involved in the earliest stages of the initiation step of chromosome replication. Here we show that MCM2-7 proteins are essential for both the formation and maintenance of the pre-RC footprint at the origin ARS305. ...

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Publisher copy:
10.1091/mbc.12.11.3658

Authors


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Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
Diffley, JF More by this author
Journal:
Molecular biology of the cell
Volume:
12
Issue:
11
Pages:
3658-3667
Publication date:
2001-11-05
DOI:
EISSN:
1939-4586
ISSN:
1059-1524
URN:
uuid:b692cbb8-ce82-4521-8f51-8edabe926600
Source identifiers:
209813
Local pid:
pubs:209813

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