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Intracellular antibody-caspase-mediated cell killing: an approach for application in cancer therapy.

Abstract:

Antibodies have been expressed inside cells in an attempt to ablate the function of oncogene products. To make intracellular antibodies more generally applicable and effective in cancer therapy, we have devised a method in which programmed cell death or apoptosis can be triggered by specific antibody-antigen interaction. When intracellular antibodies are linked to caspase 3, the "executioner" in the apoptosis pathway, and bind to the target antigen, the caspase 3 moieties are self-activated a...

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Publisher copy:
10.1073/pnas.97.22.12266

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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
97
Issue:
22
Pages:
12266-12271
Publication date:
2000-10-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:b6843552-5838-4103-a1f8-ccfba53ff650
Source identifiers:
324301
Local pid:
pubs:324301

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