Journal article icon

Journal article

Intracellular antibody-caspase-mediated cell killing: an approach for application in cancer therapy.

Abstract:

Antibodies have been expressed inside cells in an attempt to ablate the function of oncogene products. To make intracellular antibodies more generally applicable and effective in cancer therapy, we have devised a method in which programmed cell death or apoptosis can be triggered by specific antibody-antigen interaction. When intracellular antibodies are linked to caspase 3, the "executioner" in the apoptosis pathway, and bind to the target antigen, the caspase 3 moieties are self-activated a...

Expand abstract

Actions


Access Document


Publisher copy:
10.1073/pnas.97.22.12266

Authors


Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
97
Issue:
22
Pages:
12266-12271
Publication date:
2000-10-01
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Source identifiers:
324301
Language:
English
Keywords:
Pubs id:
pubs:324301
UUID:
uuid:b6843552-5838-4103-a1f8-ccfba53ff650
Local pid:
pubs:324301
Deposit date:
2013-11-16

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP