- Abstract:
-
Type 2 diabetes is characterized by diminished or inappropriate secretion of insulin, which could be a defect of either islet cell function or beta-cell mass. Quantitation of islet cell populations in postmortem pancreas demonstrates little change of beta-cell mass in type 2 diabetes. Reduction of islet cell mass (up to 30%) is associated largely with islet amyloid deposition, and the degree of amyloidosis is independent of the duration of the disease. Insulin secretory capacity is dependent ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.2337/diabetes.50.2007.S169
-
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- Journal:
- Diabetes
- Volume:
- 50 Suppl 1
- Issue:
- SUPPL. 1
- Pages:
- S169-S171
- Publication date:
- 2001-02-05
- DOI:
- EISSN:
-
1939-327X
- ISSN:
-
0012-1797
- URN:
-
uuid:b67e3d8d-653b-4dab-ae48-72c1814f3b64
- Source identifiers:
-
72772
- Local pid:
- pubs:72772
- Language:
- English
- Keywords:
- Copyright date:
- 2001
Journal article
Decreased insulin secretion in type 2 diabetes: a problem of cellular mass or function?
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