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Decreased insulin secretion in type 2 diabetes: a problem of cellular mass or function?

Abstract:

Type 2 diabetes is characterized by diminished or inappropriate secretion of insulin, which could be a defect of either islet cell function or beta-cell mass. Quantitation of islet cell populations in postmortem pancreas demonstrates little change of beta-cell mass in type 2 diabetes. Reduction of islet cell mass (up to 30%) is associated largely with islet amyloid deposition, and the degree of amyloidosis is independent of the duration of the disease. Insulin secretory capacity is dependent ...

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Publication status:
Published

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Authors


de Koning, E More by this author
Hansen, BC More by this author
Matthews, DR More by this author
Journal:
Diabetes
Volume:
50 Suppl 1
Issue:
SUPPL. 1
Pages:
S169-S171
Publication date:
2001-02-05
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
URN:
uuid:b67e3d8d-653b-4dab-ae48-72c1814f3b64
Source identifiers:
72772
Local pid:
pubs:72772

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