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Thesis

The tumour suppressor ASPP2 plays a novel role in the maintenance of epithelial cell polarity

Abstract:

ASPP2 has been identified as a haploinsufficient tumour suppressor in mice, and an activator of the apoptotic function of the p53 family. Yeast two-hybrid experiments have also shown that ASPP2 interacts with a large number of proteins involved in other major signalling pathways. The mechanism(s) of action of ASPP2 are therefore complex, and likely to involve more than just the stimulation of the apoptotic programme.

Since a study previously conducted in our laboratory revealed that...

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Institution:
University of Oxford
Oxford college:
St Catherine's College
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of

Contributors

Role:
Supervisor
Publication date:
2010
Type of award:
DPhil
Level of award:
Doctoral
URN:
uuid:b677b553-565f-4baa-b60c-ce85f1de1745
Local pid:
ora:11587

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