- Abstract:
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ASPP2 has been identified as a haploinsufficient tumour suppressor in mice, and an activator of the apoptotic function of the p53 family. Yeast two-hybrid experiments have also shown that ASPP2 interacts with a large number of proteins involved in other major signalling pathways. The mechanism(s) of action of ASPP2 are therefore complex, and likely to involve more than just the stimulation of the apoptotic programme.
Since a study previously conducted in our laboratory revealed that...
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- Publication date:
- 2010
- Type of award:
- DPhil
- Level of award:
- Doctoral
- URN:
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uuid:b677b553-565f-4baa-b60c-ce85f1de1745
- Local pid:
- ora:11587
- Language:
- English
- Keywords:
- Subjects:
- Copyright holder:
- Roberta Sottocornola
- Copyright date:
- 2010
Thesis
The tumour suppressor ASPP2 plays a novel role in the maintenance of epithelial cell polarity
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