- Abstract:
-
Invariant natural killer T (iNKT) cells are a specialised subset of T cells that are restricted to the MHC class I like molecule, CD1d. The ligands for iNKT cells are lipids, with the canonical superagonist being α-galactosylceramide, a non-mammalian glycosphingolipid. Trafficking of CD1d through the lysosome is required for the development of murine iNKT cells. Niemann-Pick type C (NPC) disease is a lysosomal storage disorder caused by dysfunction in either of two lysosomal proteins, NPC1 or...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1002/eji.201141821
-
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- Journal:
- European journal of immunology
- Volume:
- 42
- Issue:
- 7
- Pages:
- 1886-1892
- Publication date:
- 2012-07-05
- DOI:
- EISSN:
-
1521-4141
- ISSN:
-
0014-2980
- URN:
-
uuid:b6756729-99b9-4b1c-b10d-21b8b0601d0b
- Source identifiers:
-
332772
- Local pid:
- pubs:332772
- Copyright date:
- 2012
Journal article
Invariant natural killer T cells are not affected by lysosomal storage in patients with Niemann-Pick disease type C.
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