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Journal article

Control of inducible gene expression links cohesin to hematopoietic progenitor self-renewal and differentiation.

Abstract:

Cohesin is important for 3D genome organization. Nevertheless, even the complete removal of cohesin has surprisingly little impact on steady-state gene transcription and enhancer activity. Here we show that cohesin is required for the core transcriptional response of primary macrophages to microbial signals, and for inducible enhancer activity that underpins inflammatory gene expression. Consistent with a role for inflammatory signals in promoting myeloid differentiation of hematopoietic stem...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41590-018-0184-1

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Role:
Author
ORCID:
0000-0002-9338-583X
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Role:
Author
ORCID:
0000-0003-0228-5081
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Role:
Author
ORCID:
0000-0002-0394-2429
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Name:
Wellcome Trust
Grant:
091859/Z/10/Z
Publisher:
Nature Research
Journal:
Nature Immunology More from this journal
Volume:
19
Pages:
932–941
Publication date:
2018-08-20
Acceptance date:
2018-07-17
DOI:
EISSN:
1529-2916
ISSN:
1529-2908
Pmid:
30127433
Language:
English
Keywords:
Pubs id:
pubs:915968
UUID:
uuid:b66ad9cb-a547-4016-8238-b0bd63fdaa7e
Local pid:
pubs:915968
Source identifiers:
915968
Deposit date:
2019-02-27

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