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Guiding the folding pathway of DNA origami.

Abstract:

DNA origami is a robust assembly technique that folds a single-stranded DNA template into a target structure by annealing it with hundreds of short 'staple' strands. Its guiding design principle is that the target structure is the single most stable configuration. The folding transition is cooperative and, as in the case of proteins, is governed by information encoded in the polymer sequence. A typical origami folds primarily into the desired shape, but misfolded structures can kinetically tr...

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Publication status:
Published

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Publisher copy:
10.1038/nature14860

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Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Sub department:
Condensed Matter Physics
Role:
Author
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Journal:
Nature
Volume:
525
Issue:
7567
Pages:
82-86
Publication date:
2015-09-01
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
Source identifiers:
539958
Language:
English
Keywords:
Pubs id:
pubs:539958
UUID:
uuid:b66000ee-98bc-4ff2-8e93-de00f7c1f557
Local pid:
pubs:539958
Deposit date:
2015-11-12

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