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Guiding the folding pathway of DNA origami.

Abstract:

DNA origami is a robust assembly technique that folds a single-stranded DNA template into a target structure by annealing it with hundreds of short 'staple' strands. Its guiding design principle is that the target structure is the single most stable configuration. The folding transition is cooperative and, as in the case of proteins, is governed by information encoded in the polymer sequence. A typical origami folds primarily into the desired shape, but misfolded structures can kinetically tr...

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Publication status:
Published

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Publisher copy:
10.1038/nature14860

Authors


Dannenberg, F More by this author
Ouldridge, TE More by this author
Kwiatkowska, M More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Physics, Condensed Matter Physics
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Journal:
Nature
Volume:
525
Issue:
7567
Pages:
82-86
Publication date:
2015-09-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:b66000ee-98bc-4ff2-8e93-de00f7c1f557
Source identifiers:
539958
Local pid:
pubs:539958

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