Journal article icon

Journal article

The expression and localization of membrane type-1 matrix metalloproteinase in human abdominal aortic aneurysms.

Abstract:

BACKGROUND AND OBJECTIVE: Matrix metalloproteinase-2 (MMP-2) degrades both fibrillar collagens and elastin. MMP-2 is secreted as a latent 72-kd proenzyme that must be proteolytically processed to the 62-kd active form. In our laboratory we demonstrated a significant increase of active, matrix-bound MMP-2 in abdominal aortic aneurysmal (AAA) tissue compared with nonaneurysmal aorta with arteriosclerotic occlusive disease and normal aortic tissue. This increase in active MMP-2 is considered to...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1067/mva.2001.115962

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
Journal of vascular surgery
Volume:
34
Issue:
2
Pages:
316-322
Publication date:
2001-08-01
DOI:
EISSN:
1097-6809
ISSN:
0741-5214
Source identifiers:
226815
Language:
English
Keywords:
Pubs id:
pubs:226815
UUID:
uuid:b65b7b2f-7c45-47da-b819-62b7754976d9
Local pid:
pubs:226815
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP