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Journal article

The expression and localization of membrane type-1 matrix metalloproteinase in human abdominal aortic aneurysms.

Abstract:

BACKGROUND AND OBJECTIVE: Matrix metalloproteinase-2 (MMP-2) degrades both fibrillar collagens and elastin. MMP-2 is secreted as a latent 72-kd proenzyme that must be proteolytically processed to the 62-kd active form. In our laboratory we demonstrated a significant increase of active, matrix-bound MMP-2 in abdominal aortic aneurysmal (AAA) tissue compared with nonaneurysmal aorta with arteriosclerotic occlusive disease and normal aortic tissue. This increase in active MMP-2 is considered to...

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Publication status:
Published

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Publisher copy:
10.1067/mva.2001.115962

Authors


Nollendorfs, A More by this author
Greiner, TC More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Baxter, BT More by this author
Journal:
Journal of vascular surgery
Volume:
34
Issue:
2
Pages:
316-322
Publication date:
2001-08-05
DOI:
EISSN:
1097-6809
ISSN:
0741-5214
URN:
uuid:b65b7b2f-7c45-47da-b819-62b7754976d9
Source identifiers:
226815
Local pid:
pubs:226815

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