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Journal article

Impaired CD28-mediated interleukin 2 production and proliferation in stress kinase SAPK/ERK1 kinase (SEK1)/mitogen-activated protein kinase kinase 4 (MKK4)-deficient T lymphocytes.

Abstract:

The dual specific kinase SAPK/ERK1 kinase (SEK1; mitogen-activated protein kinase kinase 4/Jun NH2 terminal kinase [ JNK] kinase) is a direct activator of stress-activated protein kinases ([SAPKs]/JNKs) in response to CD28 costimulation, CD40 signaling, or activation of the germinal center kinase. Here we show that SEK1(-/-) recombination-activating gene (RAG)2(-/-) chimeric mice have a partial block in B cell maturation. However, peripheral B cells displayed normal responses to IL-4, IgM, an...

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Publication status:
Published

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Publisher copy:
10.1084/jem.186.6.941

Authors


Nishina, H More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Oliveira-dos-Santos, AJ More by this author
Kozieradzki, I More by this author
Fischer, KD More by this author
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Journal:
The Journal of experimental medicine
Volume:
186
Issue:
6
Pages:
941-953
Publication date:
1997-09-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:b658e19c-342a-4fa1-955b-0ebfa9fddad0
Source identifiers:
469204
Local pid:
pubs:469204

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