Journal article
Impaired CD28-mediated interleukin 2 production and proliferation in stress kinase SAPK/ERK1 kinase (SEK1)/mitogen-activated protein kinase kinase 4 (MKK4)-deficient T lymphocytes.
- Abstract:
-
The dual specific kinase SAPK/ERK1 kinase (SEK1; mitogen-activated protein kinase kinase 4/Jun NH2 terminal kinase [ JNK] kinase) is a direct activator of stress-activated protein kinases ([SAPKs]/JNKs) in response to CD28 costimulation, CD40 signaling, or activation of the germinal center kinase. Here we show that SEK1(-/-) recombination-activating gene (RAG)2(-/-) chimeric mice have a partial block in B cell maturation. However, peripheral B cells displayed normal responses to IL-4, IgM, an...
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- Publication status:
- Published
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- Publisher copy:
- 10.1084/jem.186.6.941
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Authors
Bibliographic Details
- Journal:
- The Journal of experimental medicine
- Volume:
- 186
- Issue:
- 6
- Pages:
- 941-953
- Publication date:
- 1997-09-05
- DOI:
- EISSN:
-
1540-9538
- ISSN:
-
0022-1007
- URN:
-
uuid:b658e19c-342a-4fa1-955b-0ebfa9fddad0
- Source identifiers:
-
469204
- Local pid:
- pubs:469204
Item Description
- Language:
- English
- Keywords:
Terms of use
- Copyright date:
- 1997
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