Journal article icon

Journal article

Induction of depressed mood disrupts emotion regulation neurocircuitry and enhances pain unpleasantness

Abstract:

Background: Depressed mood alters the pain experience. Yet, despite its clear clinical relevance, little is known about the cognitive and neural mechanisms underlying this phenomenon. We tested an experimental manipulation to unravel the interaction between depressed mood and pain. We hypothesized that dysregulation of the neural circuitry underlying emotion regulation is the mechanism whereby pain processing is affected during depressed mood.

Methods: Using functional magnetic reson...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Research group:
Centre for Functional Magnetic Resonance Imaging of the Brain
Role:
Author
More by this author
Institution:
University of Oxford
Research group:
Centre for Functional Magnetic Resonance Imaging of the Brain
Department:
Medical Sciences Division - Anaesthetics,Nuffield Department of
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
More by this author
Institution:
Harvard Medical School. Brigham & Women's Hospital, Chestnut Hill, Massachusetts
Department:
Department of Anesthesiology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
Expand authors...

Contributors

More from this funder
Funding agency for:
Leknes, S
More from this funder
Funding agency for:
Holmes, E
Medical Research Council of Great Britain and Northern Ireland More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Biological Psychiatry Journal website
Volume:
67
Issue:
11
Pages:
1083-1090
Publication date:
2010-06-01
DOI:
ISSN:
0006-3223
Language:
English
Keywords:
Subjects:
UUID:
uuid:b65328fc-1d77-46ca-859d-113c78511b2f
Local pid:
ora:5375
Deposit date:
2011-05-26

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP