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Induction of depressed mood disrupts emotion regulation neurocircuitry and enhances pain unpleasantness

Abstract:

Background: Depressed mood alters the pain experience. Yet, despite its clear clinical relevance, little is known about the cognitive and neural mechanisms underlying this phenomenon. We tested an experimental manipulation to unravel the interaction between depressed mood and pain. We hypothesized that dysregulation of the neural circuitry underlying emotion regulation is the mechanism whereby pain processing is affected during depressed mood.

Methods: Using functional magnetic reson...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Research group:
Centre for Functional Magnetic Resonance Imaging of the Brain
Department:
Medical Sciences Division - Psychiatry
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Institution:
University of Oxford
Research group:
Centre for Functional Magnetic Resonance Imaging of the Brain
Department:
Medical Sciences Division - Anaesthetics,Nuffield Department of
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Institution:
University of Oxford
Department:
Medical Sciences Division - Psychiatry
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Institution:
Harvard Medical School. Brigham & Women's Hospital, Chestnut Hill, Massachusetts
Department:
Department of Anesthesiology
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Institution:
University of Oxford
Department:
Medical Sciences Division - Psychiatry
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Funding agency for:
Siri Leknes
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Funding agency for:
Emily A. Holmes
Medical Research Council of Great Britain and Northern Ireland More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Biological Psychiatry Journal website
Volume:
67
Issue:
11
Pages:
1083-1090
Publication date:
2010-06-05
DOI:
ISSN:
0006-3223
URN:
uuid:b65328fc-1d77-46ca-859d-113c78511b2f
Local pid:
ora:5375

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