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Fibroblasts prevent apoptosis of IL-2-deprived T cells without inducing proliferation: a selective effect on Bcl-XL expression.

Abstract:

The apoptosis of human cytokine-deprived activated T cells can be prevented by a soluble mediator secreted by fibroblasts, epithelial and endothelial cells, and this rescue occurs with fibroblasts from different species. Fractionation of W138 fibroblast-conditioned medium indicated that the survival-promoting agent(s) were > 30,000 MW. The continuous presence of the survival factor was required for prevention of apoptosis, which did not involve the induction of proliferation. Nevertheless,...

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Journal:
Immunology
Volume:
89
Issue:
3
Pages:
397-404
Publication date:
1996-11-01
DOI:
EISSN:
1365-2567
ISSN:
0019-2805
Source identifiers:
35999

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