Journal article
Fibroblasts prevent apoptosis of IL-2-deprived T cells without inducing proliferation: a selective effect on Bcl-XL expression.
- Abstract:
-
The apoptosis of human cytokine-deprived activated T cells can be prevented by a soluble mediator secreted by fibroblasts, epithelial and endothelial cells, and this rescue occurs with fibroblasts from different species. Fractionation of W138 fibroblast-conditioned medium indicated that the survival-promoting agent(s) were > 30,000 MW. The continuous presence of the survival factor was required for prevention of apoptosis, which did not involve the induction of proliferation. Nevertheless,...
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- Publisher copy:
- 10.1046/j.1365-2567.1996.d01-759.x
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Authors
Bibliographic Details
- Journal:
- Immunology
- Volume:
- 89
- Issue:
- 3
- Pages:
- 397-404
- Publication date:
- 1996-11-01
- DOI:
- EISSN:
-
1365-2567
- ISSN:
-
0019-2805
- Source identifiers:
-
35999
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:35999
- UUID:
-
uuid:b65187ee-79dd-4b3e-8e62-553ba5758f96
- Local pid:
- pubs:35999
- Deposit date:
- 2012-12-20
Terms of use
- Copyright date:
- 1996
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