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A prospective, open-label, randomized trial of doxycycline versus azithromycin for the treatment of uncomplicated murine typhus

Abstract:
Background Murine typhus, or infection with Rickettsia typhi, is a global but neglected disease without randomised clinical trials to guide antibiotic therapy. Doxycycline is commonly used but without objective evidence for optimum treatment duration. Azithromycin is a potential alternative. Methods A prospective, open, randomised trial was conducted in non-pregnant, consenting inpatient adults with rapid diagnostic test evidence for uncomplicated murine... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1093/cid/ciy563

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More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Tropical Medicine
Role:
Author
ORCID:
0000-0003-0734-2022
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Tropical Medicine
Role:
Author
Expand authors...
Wellcome Trust More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
Clinical Infectious Diseases Journal website
Volume:
68
Issue:
5
Pages:
738–747
Publication date:
2018-07-18
Acceptance date:
2018-06-29
DOI:
ISSN:
1537-6591 and 1058-4838
Pubs id:
pubs:891352
URN:
uri:b64f4fb1-173d-42af-a0b9-1cef08c5f309
UUID:
uuid:b64f4fb1-173d-42af-a0b9-1cef08c5f309
Local pid:
pubs:891352

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